Coronavirus and influenza compositions and methods for using them

An immunogenic composition comprising:

• (a) a severe acute respiratory syndrome coronavirus-2 S (SARS-COV-2 S) glycoprotein in the form of a detergent-core nanoparticle, wherein the detergent is a non-ionic detergent, and wherein the SARS-COV-2 S glycoprotein comprises an inactivated furin cleavage site having the amino acid sequence QQAQ (SEQ ID NO:
• 7) and proline at each of amino acids 973 and 974, as numbered with respect to a polypeptide having the sequence of SEQ ID NO:
• 2;
• (b) at least three hemagglutinin (HA) glycoproteins, wherein each HA glycoprotein is from a different influenza strain, and wherein each HA glycoprotein is in the form of a detergent-core nanoparticle or in the form of a HaSMaN (hemagglutinin saponin matrix nanoparticle);
• and
• (c) a pharmaceutically acceptable buffer;
• wherein the composition comprises from 20 μg to about 65 μg of HA glycoprotein per strain and from about 5 μg to about 50 μg of SARS-COV-2 S glycoprotein.