Vaccines against Chlamydia sp
AssigneeStatens Serum Institut
InventorsFrank Follmann, Ida Rosenkrands, Anja Olsen, Peter Andersen
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Abstract
The present invention describes an efficient vaccine against a Chlamydia trachomatis (Ct). The vaccine is based on recombinant fusion molecules that are capable of generating a high titered neutralizing antibody response that is protective against various Ct serovars. Our invention furthermore describe the combination of these antibody promoting fragments with Ct antigens that are targets for T cells with the aim to provide a vaccine that activate both arms of the immune system.
Claims19
A polypeptide comprising 3 or more homologous immuno-repeat units of surface exposed fragments of the major outer membrane protein (MOMP), wherein each immuno-repeat comprises an amino acid sequence which comprises the variable domain 1 (VD1) region of the MOMP from a serotype of a Chlamydia or Chlamydiaphila species selected from the group consisting of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydiaphila abortus.
A polypeptide comprising more than one immuno-repeat unit of surface exposed fragments of variable domain 1 (VD1) in major outer membrane protein (MOMP) from a serotype of Chlamydia trachomatis, wherein the more than one immuno-repeat units comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 9-14 and 45-48.
Dependencies are inferred from the claim text.