Methods of treatment of a cytokine storm
AssigneeLoma Linda University Health
InventorsDavid J. Baylink, Xiaolei Tang, Amir Abdipour, Samiksha Wasnik
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Abstract
Provided here are methods for treating a cytokine storm in a subject. One such method includes the administration of a therapeutically effective amount of an Insulin-like Growth Factor (IGF-1), a Ca2+-release-activated Ca2+ (CRAC) channel inhibitor, or combinations thereof. Methods include treatment of acute lung injury or acute kidney injury with a therapeutically effective amount of 3,5-bis(trifluoromethyl) pyrazole derivative or teriflunomide, either individually or in combination with IGF-1.
Claims4
A method for treating acute lung injury and/or acute kidney injury in a subject-experiencing a cytokine storm, the method comprising:
- Administering to the subject a therapeutically effective amount of IGF-1 and an agent to decrease cytosolic calcium, wherein the agent to decrease cytosolic calcium is selected from among an anti-CRAC channel antibody, 3,5-bis(trifluoromethyl) pyrazole derivative (BTP-2), 2-Aminoethoxydiphenyl borate (2-APB), and/or teriflunomide.
Dependencies are inferred from the claim text.