Apparatus, methods, and systems for providing pharmaceutical compositions in the form of droplets for aerosol administration and inhalation delivery

A pharmaceutical composition stored in a removable capsule and administered from the removable capsule in the form of droplets into a patient's mouth via a mouthpiece of an atomizer for at least one of inhalation and respiratory absorption by the patient;

• wherein the pharmaceutical composition is an aqueous solution comprising sodium chloride present in an amount of from 0.6% to 3% by weight per volume of the pharmaceutical composition;
• at least one active ingredient present in a total amount of from 0.01% to 25% by weight per volume of the pharmaceutical composition, the at least one active ingredient selected from the group consisting of naloxone, yohimbine, albuterol, epinephrine, buprenorphine, semaglutide, glucagon-like peptide-1, and exosomes;
• and having a pH from 3 to 7.5;
• wherein the removable capsule comprises:
• a chamber;
• a vibrating mesh membrane at a lower end portion of the removable capsule, the vibrating mesh membrane in fluid communication with the chamber;
• the pharmaceutical composition disposed within the chamber;
• and
• wherein the pharmaceutical composition is prepared into the form of droplets by a process comprising:
• inserting the removable capsule into a receiving section of the atomizer, activating the atomizer to power the vibrating mesh membrane to undergo piezoelectric vibration at a frequency of from 25 kilohertz to 400 kilohertz and causing the pharmaceutical composition in the form of the aqueous solution to pass through the vibrating mesh membrane to convert the pharmaceutical composition into the form of droplets;
• wherein each droplet formed by passing through the vibrating mesh membrane has a diameter of from 0.5 to 5 microns and wherein each droplet consists of the pharmaceutical composition,
• wherein the removable capsule comprises a plurality of electrical contacts disposed on a radial surface of a protruding body of the removable capsule, the protruding body extending substantially an entire length of a lower portion of the removable capsule;
• wherein the plurality of electrical contacts on the removable capsule electrically mate with a second plurality of electrical contacts in the receiving section of the atomizer;
• and
• wherein activating the vibrating mesh membrane comprises engaging the electrical contacts on the removable capsule.