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US 12,714,694 B2Granted
Thiohydantoin derivatives and uses thereof
AssigneeCelros Biotech
InventorsYun Soo Bae, Da Un Jeong
Life of this patent
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Abstract
The present invention relates to a thiohydantoin derivative and a composition for preventing or treating NADPH oxidase (NOX)-associated diseases comprising same, and can be used to treat NADPH oxidase (NOX)-associated diseases through excellent actions on NOX inhibition.
Claims18
A compound represented by the following Chemical Formula 3:
- wherein
- Ra is hydrogen, a hydroxyl group or a C1-C4 alkoxy group,
- Rb is a C1-C6 straight chain or branched chain alkyl group, a C3-C10 cycloalkyl group, or a —(C1-C3 alkyl) C6-C12 aryl group,
- Rc is hydrogen or a C1-C4 alkyl group, and
- n is any integer from 1 to 4.
2 more elements
A method for treating NADPH oxidase (NOX)-associated diseases comprising:
- administering, to a subject in need thereof, a therapeutically effective amount of a compound represented by the following Chemical Formula 3, an isomer or a pharmaceutically acceptable salt thereof:
- wherein
- Ra is hydrogen, a hydroxyl group or a C1-C4 alkoxy group,
- Rb is a C1-C6 straight chain or branched chain alkyl group, a C3-C10 cycloalkyl group, or a —(C1-C3 alkyl) C6-C12 aryl group,
- Rc is hydrogen or a C1-C4 alkyl group, and
- n is any integer from 1 to 4,
- wherein the NADPH oxidase (NOX)-associated disease is any one selected from the group consisting of psoriasis, rheumatoid arthritis, osteoarthritis, restenosis, atherosclerosis, ulcers, liver cirrhosis, glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombotic microangiopathy, organ transplant rejection, diabetes, hypertension, cardiac hypertrophy, heart failure, cancer, autoimmune diseases, inflammatory diseases, degenerative brain diseases, and retinal diseases.
4 more elements
Dependencies are inferred from the claim text.