Method of reducing food intake in a healthy mammal

A method of reducing food intake in a healthy mammal in need of reducing food intake, the method comprising administering to the healthy mammal an oral composition comprising gut peptide hormone response-generating microparticles, in which the microparticles comprise lipid contained within a gastric-resistant, ileal-sensitive carrier, wherein the composition is orally administered 1-3 hours prior to a meal, and in which the carrier comprises a double-coating of denatured crosslinked plant or dairy protein configured for distal bowel release, wherein administering the composition to the healthy mammal generates a gut peptide hormone response, thereby reducing food intake in the healthy mammal and wherein the microparticles are formed by a method comprising the steps of:

• providing solid lipid microparticles on a fluidised bed;
• spraying a denatured protein solution onto the bed to coat the lipid particles and form microparticles;
• and
• drying the microparticles,
• wherein a second denatured protein solution is sprayed on to the dried microparticles.