Closed system for sterile drug preparation and administration

A method comprising:

• at least partially inserting a medication port and an IV tubing port that extend from a bottom region of an infusion bag into an infusion-bag receptacle of a sterile closed system, such that an infusion-bag seal of the sterile closed system, when in a sealing state, makes an airtight seal with respective external surfaces of the medication port and the IV tubing port of the infusion bag within the infusion-bag receptacle, wherein the sterile closed system further comprises:
• an airtight enclosure, shaped so as to define an enclosure interior;
• a medication-vial port, which is accessible from outside the airtight enclosure;
• a medication-port-interface needle, disposed within the enclosure interior;
• an IV-tubing-port-interface spike, disposed within the enclosure interior;
• medication-preparation tubing, which is shaped so as to define (a) a syringe-interface end, (b) a medication-vial-interface end, which in fluid communication with the medication-vial port, and (c) a medication-port-interface end, which (i) is disposed within the enclosure interior, and (ii) which is in fluid communication with the medication-port-interface needle;
• and
• medication-delivery tubing, which is shaped so as to define an IV-tubing-port-interface end, which is in fluid communication with the IV-tubing-port-interface spike;
• sealingly coupling the medication-vial port to a medication vial containing a medication, so as to couple the medication vial to the sterile closed system;
• while the infusion-bag seal is in the sealing state, sealingly coupling the medication-port-interface needle to the medication port of the infusion bag without breaking the airtight seal between the infusion-bag seal and the respective external surfaces of the medication port and the IV tubing port of the infusion bag;
• drawing a volume of IV solution from the infusion bag into a syringe barrel of a syringe sealingly coupled in fluid communication with the syringe-interface end of the medication-preparation tubing, by withdrawing a syringe handle accessible from outside the airtight enclosure;
• while the syringe remains sealingly coupled in fluid communication with the syringe-interface end, transferring the volume of the IV solution from the syringe barrel to the medication vial by pushing the syringe handle;
• while the medication vial remains coupled to the sterile closed system, agitating the medication vial to mix the medication with the volume of the IV solution to produce a diluted medication;
• while the medication vial remains coupled to the sterile closed system and the syringe remains sealingly coupled in fluid communication with the syringe-interface end, transferring the diluted medication from the medication vial to the syringe barrel by withdrawing the syringe handle;
• while the syringe remains sealingly coupled in fluid communication with the syringe-interface end, transferring the diluted medication from the syringe barrel to the infusion bag by pushing the syringe handle;
• and
• while the infusion-bag seal is in the sealing state, sealingly coupling the IV-tubing-port-interface spike to the IV tubing port of the infusion bag without breaking the airtight seal between the infusion-bag seal and the respective external surfaces of the medication port and the IV tubing port of the infusion bag.