Biosignal-based navigation of electrophysiological mapping baskets using statistical shape models

A system configured to determine three-dimensional location of electrodes of an intra-cardiac electrophysiological (EP) mapping basket, the basket being configured to be disposed inside or near an atrium or other heart chamber of a patient's heart, the EP mapping basket comprising a plurality of electrodes arranged in a predetermined spatial configuration, the system comprising:

• a data acquisition or recording device, and a computing device, the data acquisition or recording device and computing device being operably connected to the EP mapping basket and the electrodes thereof, the data acquisition or recording device being configured to record or acquire a plurality of intra-cardiac signals while the basket is positioned at different locations inside or near the atrium or other heart chamber using the plurality of electrodes, the recorded or acquired intra-cardiac signals each having at least one electrode associated therewith, wherein each electrode records cardiac electrical activity from a specific three-dimensional location;
• wherein the computing device is configured to isolate or extract ventricular signals from at least some of the recorded or acquired intra-cardiac signals, using signal processing techniques that differentiate ventricular electrical activity from atrial electrical activity based on characteristic waveform morphologies and timing relationships, and the computing device is further configured to determine, using the extracted or isolated ventricular signals, a statistical shape model of the EP mapping basket by analyzing spatial relationships between the isolated ventricular signals and correlating signal propagation patterns with known cardiac anatomical structures, wherein the statistical shape model accounts for dynamic deformation of the basket during cardiac motion and the three-dimensional locations of the electrodes inside or near the atrium or other heart chamber that are associated with each or a plurality of isolated or extracted ventricular signals by applying the statistical shape model to the isolated ventricular signals in at least near real-time during the cardiac mapping procedure, wherein the computing device is further configured to display the determined electrode locations on a visualization system to guide clinical decision-making during the electrophysiological procedure.