Neurodegenerative and amyotrophic model animal
AssigneeTokyo Metropolitan Institute of Medical Science
InventorsMakoto Murakami, Tetsuya Hirabayashi
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Abstract
Provided are: a neurodegenerative model animal also exhibiting amyotrophy, the neurodegenerative model animal comprising a nonhuman animal from which both the PNPLA6 and PNPLA7 genes have been deleted; and a method for screening a drug for neurodegenerative disease or a drug for a disease that causes amyotrophy, the screening method involving causing contact of a substance to be examined with said animal or with a biological sample collected from the animal, and using, as an index, an improvement effect with regards to neurodegeneration or amyotrophy of the nonhuman animal or biological sample after contact with the substance to be examined.
Claims18
A neurodegenerative disease model animal with amyotrophy, comprising a nonhuman animal deficient in both the PNPLA6 and PNPLA7 genes wherein PNPLA6 and PNPLA7 genes are deleted in a neuron- or glial-cell-specific manner.
A model cell or organoid for a neurodegenerative disease with amyotrophy, comprising an animal cell deficient in both the PNPLA6 and PNPLA7 genes.
Dependencies are inferred from the claim text.