Systems and methods for gene variant grouping and visualization

A system for determining relationships between gene variants of a gene, the gene variants being related to one or more cancers and being correlated to a treatment response of the one or more cancers to one or more medications, the system comprising:

• at least one processor;
• and
• at least one computer memory storing instructions, that, when executed by the at least one processor, perform a method of:
• accessing, using at least one processor, a database comprising information about the gene variants, the information including at least information indicative of a treatment response of a first gene variant of the gene variants to one or more treatments;
• categorizing, using the at least one processor, the information about the gene variants within a plurality of groups by:
• determining, based on the information about the gene variants, one or more attributes of respective mutations associated with the gene variants;
• determining whether the information about the gene variants includes (1) information indicating a gene group, the gene group including a particular gene variant and (2) information indicating the gene group includes a particular group of the plurality of groups associated with an attribute of the particular gene variant;
• and
• categorizing the gene variants within the plurality of groups based on determining the information indicates the determined one or more attributes and, each of the plurality of groups associated with an attribute of respective mutations associated with the gene variants;
• generating, using the at least one processor, hierarchical relationships between each group of the plurality of groups, wherein the hierarchical relationships form a directed acyclic graph, the hierarchical relationships between each group indicating relationships between the attributes of respective mutations associated with the gene variants;
• generating, using the at least one processor, a visualization of the hierarchical relationships between each group of the plurality of groups;
• and
• displaying, on a user interface of a computing device, the visualization.

At least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by at least one processor, cause the at least one processor to perform a method for determining relationships between gene variants of a gene, the gene variants being related to one or more cancers and being correlated to a treatment response of the one or more cancers to one or more medications, the method comprising:

• accessing a database comprising information about the gene variants, the information including at least information indicative of a treatment response of a first gene variant of the gene variants to one or more treatments;
• categorizing the information about the gene variants within a plurality of groups by:
• determining, based on the information about the gene variants, one or more attributes of respective mutations associated with the gene variants;
• determining whether the information about the gene variants includes (1) information indicating a gene group, the gene group including a particular gene variant and (2) information indicating the gene group includes a particular group of the plurality of groups associated with an attribute of the particular gene variant;
• and
• categorizing the gene variants within the plurality of groups based on determining the information indicates the determined one or more attributes and, each of the plurality of groups associated with an attribute of respective mutations associated with the gene variants;
• generating hierarchical relationships between each group of the plurality of groups, wherein the hierarchical relationships form a directed acyclic graph, the hierarchical relationships between each group indicating relationships between the attributes of respective mutations associated with the gene variants;
• generating, using the at least one processor, a visualization of the hierarchical relationships between each group of the plurality of groups;
• and
• displaying, on a user interface of a computing device, the visualization.