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US 12,712,082 B2Granted
Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
AssigneeCleerly, Inc.
InventorsJames K. Min, James P. Earls, Shant Malkasian, Hugo Miguel Rodrigues Marques, Chung Chan, Shai Ronen
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Abstract
Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.
Claims20
A computer-implemented method of assessing microcirculatory resistance of coronary microvasculature based on non-invasive medical image analysis, the computer-implemented method comprising:
- accessing, by a computer system, a first medical image of a subject, wherein the first medical image of the subject is obtained at a first point in time after injection of a contrast dye to the subject;
- accessing, by the computer system, a second medical image of the subject, wherein the second medical image of the subject is obtained at a second point in time after injection of the contrast dye to the subject;
- analyzing, by the computer system, the first medical image and the second medical image to identify a coronary artery;
- mapping, by the computer system, myocardium subtended by the coronary artery in the first medical image and the second medical image;
- analyzing, by the computer system, a difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image, the difference in radiodensity arising from flow of the contrast dye through microvasculature of the myocardium subtended by the coronary artery;
- determining, by the computer system, a generated measure of per-artery microcirculatory resistance of the coronary artery by relating the difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image to a difference in time between the first point in time and the second point in time;
- and
- determining, by the computer system, an assessment of microcirculatory resistance of the coronary artery based at least in part on comparing the generated measure of the per-artery microcirculatory resistance of the coronary artery to a plurality of reference measures of per-artery microcirculatory resistance, the plurality of reference measures of per-artery microcirculatory resistance derived from a plurality of other subjects, wherein the assessment of microcirculatory resistance of the coronary artery is configured to be utilized to determine a treatment for the subject, wherein the computer system comprises a computer processor and an electronic storage medium.
5 more elements
A system for image-based assessment of microcirculatory resistance, the system comprising:
- a non-transitory computer storage medium configured to at least store computer-executable instructions;
- and
- one or more computer hardware processors in communication with the non-transitory computer storage medium, the one or more computer hardware processors configured to execute the computer-executable instructions to at least:
- access a first medical image of a subject, wherein the first medical image of the subject is obtained at a first point in time after injection of a contrast dye to the subject;
- access a second medical image of a subject, wherein the second medical image of the subject is obtained at a second point in time after injection of the contrast dye to the subject;
- analyze the first medical image and the second medical image to identify a coronary artery;
- map myocardium subtended by the coronary artery in the first medical image and the second medical image;
- analyze a difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image, the difference in radiodensity arising from flow of the contrast dye through microvasculature of the myocardium subtended by the coronary artery;
- determine a generated measure of per-artery microcirculatory resistance of the coronary artery by relating the difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image to a difference in time between the first point in time and the second point in time;
- and
- determine an assessment of microcirculatory resistance of the coronary artery based at least in part on comparing the generated measure of the per-artery microcirculatory resistance of the coronary artery to a plurality of reference measures of per-artery microcirculatory resistance, the plurality of reference measures of per-artery microcirculatory resistance derived from a plurality of other subjects, wherein the assessment of microcirculatory resistance of the coronary artery is configured to be utilized to determine a treatment for the subject.
8 more elements
A non-transitory computer readable medium configured for image-based assessment of microcirculatory resistance, the non-transitory computer readable medium having program instructions for causing a hardware processor to perform a method of:
- accessing a first medical image of a subject, wherein the first medical image of the subject is obtained at a first point in time after injection of a contrast dye to the subject;
- accessing a second medical image of a subject, wherein the second medical image of the subject is obtained at a second point in time after injection of the contrast dye to the subject;
- analyzing the first medical image and the second medical image to identify a coronary artery;
- mapping myocardium subtended by the coronary artery in the first medical image and the second medical image;
- analyzing a difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image, the difference in radiodensity arising from flow of the contrast dye through microvasculature of the myocardium subtended by the coronary artery;
- determining a generated measure of per-artery microcirculatory resistance of the coronary artery by relating the difference in radiodensity between the myocardium subtended by the coronary artery in the first medical image and the second medical image to a difference in time between the first point in time and the second point in time;
- and
- determining an assessment of microcirculatory resistance of the coronary artery based at least in part on comparing the generated measure of the per-artery microcirculatory resistance of the coronary artery to a plurality of reference measures of per-artery microcirculatory resistance, the plurality of reference measures of per-artery microcirculatory resistance derived from a plurality of other subjects,
- wherein the assessment of microcirculatory resistance of the coronary artery is configured to be utilized to determine a treatment for the subject.
6 more elements
Dependencies are inferred from the claim text.