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US 12,710,419 B2Granted
3D sensors for simultaneous detection of bioelectronic and biomechanical signals in tissue
AssigneeUniversity of Massachusetts
InventorsJun Yao, Hongyan Gao
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Abstract
The present disclosure presents biosensor devices, systems, and related methods. One such biosensor device comprises a substrate; a semiconductive channel member suspending between a pair of contacts on the substrate, wherein the semiconductive channel member comprises a convex protruding channel structure; and wherein the convex protruding channel structure is configured to detect both electrical and mechanical cellular responses. Other devices, systems, and methods are also presented.
Claims20
A biosensor device comprising:
- a substrate;
- a semiconductive channel member suspending between a pair of contacts on the substrate, wherein the semiconductive channel member comprises a convex protruding channel structure;
- and
- wherein the convex protruding channel structure is configured to simultaneously detect both electrical and mechanical cellular responses.
1 more element
A biosensing method comprising:
- positioning a biosensor device under biological tissue, wherein the biosensor device comprises:
- a substrate;
- and
- a semiconductive channel member suspending between a pair of contacts on the substrate, wherein the semiconductive channel member comprises a convex protruding channel structure;
- detecting an electrical cellular response of the biological tissue that is sensed by the biosensor device via a field effect;
- and
- detecting a mechanical cellular response of the biological tissue that is sensed by the biosensor device via a piezoresistive effect simultaneously with the detection of the electrical cellular response of the biological tissue.
4 more elements
Dependencies are inferred from the claim text.