Resonant nanophotonic biosensors
AssigneeThe Board of Trustrees of the Leland Stanford Junior University
InventorsJennifer A. Dionne, John Abendroth, Mark Lawrence, Jack Hu, Fareeha Safir, Jefferson Dixon, Stefanie S. Jeffrey
Life of this patent
Estimating the term…
Abstract
Optical sensing of biological targets is provided using a metasurface having guided mode resonances with electric field profiles that extend out from the metasurface. Surface functionalization of such metasurfaces can be used to provide sensing for biological targets, such as nucleic acids, proteins, small molecules, extracellular vesicles, and whole cells. Binding of the target to the surface functionalization can affect the resonance wavelength of the guided mode resonances, thereby providing a sensitive assay for the biological targets.
Claims20
An apparatus comprising:
- an electromagnetic metasurface, surface functionalized for selective molecular binding of one or more molecules or analytes in proximity to the electromagnetic metasurface, including one or more waveguides disposed on a substrate;
- wherein each of the one or more waveguides is to support one or more guided mode resonances and has a corresponding longitudinal perturbation, and a selected one or more of the guided mode resonances is to couple free-space radiation by the corresponding longitudinal perturbation;
- and the selected one or more guided mode resonances, in operation, have electric field distributions that extend outside the electromagnetic metasurface.
A method comprising:
- using a functionalized electromagnetic metasurface, including one or more waveguides disposed on a substrate, to selectively molecular bind one or more molecules or analytes in proximity to the electromagnetic metasurface, wherein each of the one or more waveguides supports one or more guided mode resonances and has a corresponding longitudinal perturbation;
- and causing a selected one or more of the guided mode resonances to couple free-space radiation by the corresponding longitudinal perturbation and the selected one or more guided mode resonances to have electric field distributions that extend outside the electromagnetic metasurface.
Dependencies are inferred from the claim text.