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US 12,710,406 B2Granted
Chromatographic-like separation using sample droplet ejection
AssigneeDH Technologies Development Pte. Ltd.
InventorsDavid Cox, Chang Liu
Life of this patent
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Abstract
Disclosed are methods for separating target and non-target analytes in a sample. The methods can utilize an acoustic droplet ejector (ADE) and an open port interface (OPI) to achieve liquid chromatography (LC)-like separation for an analytical instrument such as, for example, a mass spectrometer.
Claims20
A method comprising:
- combining separation media with a sample solution;
- separating the separation media from the sample solution;
- retaining the separation media in a reservoir containing an eluent to form an eluent solution having an eluent concentration;
- generating a synthetic chromatogram by repeatedly:
- ejecting a volume of eluent solution from the reservoir into a sampling interface,
- capturing the volume of eluent solution with the sampling interface and transferring the captured volume to a mass spectrometer for mass analysis,
- mass analyzing eluent ions, and
- increasing the eluent concentration of the eluent solution until a target concentration is reached.
5 more elements
A method comprising:
- combining separation media with a sample solution;
- separating the separation media from the sample solution;
- retaining the separation media in a plurality of reservoirs, each reservoir containing a different concentration of an eluent to form a plurality of eluent solutions at different eluent concentrations;
- generating a synthetic chromatogram by:
- sequentially ejecting from each reservoir of the plurality of reservoirs a volume of eluent solution into a sampling interface,
- capturing the volume of eluent solution with the sampling interface and transferring the captured volume to a mass spectrometer to generate eluent ions for mass analysis, and
- mass analyzing the eluent ions.
4 more elements
Dependencies are inferred from the claim text.