Engineered adenovirus vectors and uses thereof
OwnerRichard Lowenthalinventor
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Abstract
Disclosed herein relates to a replication competent recombinant adenovirus comprising restriction enzyme sites in an E3 region to insert a gene of interest. Also disclosed herein is a method for generating the replication competent recombinant adenovirus and a pharmaceutical composition comprising the adenovirus for use in treating a disease or a condition.
Claims19
A replication competent recombinant oncolytic adenovirus comprising restriction sites comprising an I-CeuI restriction site, a PI-SceI restriction site, or a combination thereof in an E3 region, wherein the E3 region does not comprise a deletion as compared to a wild type adenovirus of the same serotype.
Dependencies are inferred from the claim text.