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US 12,709,744 B2Granted
Xylanase variants and polynucleotides encoding same
AssigneeNovozymes A/S
InventorsAnnette Helle Johansen, Steffen Danielsen, Frank Winther Rasmussen, Peter Kamp Hansen, Roland Alexander Pache
Life of this patent
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Abstract
The present invention relates to xylanase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; compositions comprising the xylanase variants and methods of using the variants.
Claims26
A xylanase variant having xylanase activity and improved thermostability compared to a parent xylanase, wherein the variant has at least 90% sequence identity to SEQ ID NO:
- 1 and comprises one or more substitutions relative to the parent xylanase, said one or more substitutions occurring at one or more positions corresponding to positions 14, 18, 50, 145, 146, 176, 179, 197, 298 and 299 of SEQ ID NO:
- 1 and comprising at least one substitution with an amino acid residue selected from the group consisting of C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y, with the proviso that the substituted amino acid residue is different from the naturally-occurring amino acid residue in that position.
Dependencies are inferred from the claim text.