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US 12,709,739 B2Granted
Engineered cells secreting therapeutic enzymes
AssigneeCartesian Therapeutics, Inc.
InventorsYi Zhang, C. Andrew Stewart, Shaji Daniel, Metin Kurtoglu, Murat V. Kalayoglu
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Abstract
Provided herein are mammalian cells comprising a first exogenous nucleic acid encoding a DNAse protein and a second exogenous nucleic acid encoding another DNAse protein, such as DNASE1 protein and DNASE1L3 protein, that have improved properties, including the ability to degrades extracellular chromatin and remove Neutrophil Extracellular Traps (NETs). Use of these cells, including the use in the treatment of a subject in need thereof, is also contemplated.
Claims15
An isolated mammalian cell modified to express:
- at least one DNAse enzyme;
- and
- at least one anti-B-cell maturation antigen (BCMA) antibody.
Dependencies are inferred from the claim text.