Advanced glycation end product analogues
AssigneePhytoquest Limited
InventorRobert James Nash
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Abstract
Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).
Claims5
A method for treating an AGE-mediated disease comprising administering an effective amount of a composition comprising an isolated fructose amino acid, said fructose amino acid being N2-b-D-Fructopyranos-1-yl-Arginine (5-carbamimidamido-2-{[(2,3,4,5-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl]amino}pentanoic acid) of the formula:
- or a pharmaceutically acceptable salt thereof, to a human in need thereof, wherein the isolated fructose amino acid is present in the composition at a level of at least 5% w/w, 10% w/w;
- 15% w/w;
- 20% w/w;
- 25% w/w;
- 30% w/w;
- 35% w/w;
- 40% w/w;
- 45% w/w;
- 50% w/w, 60% w/w, 70% w/w, 80% w/w, 90% w/w, or 99% w/w (on a dry weight basis).
Dependencies are inferred from the claim text.