STAT6 modulators and uses thereof
AssigneeRecludix Pharma, Inc.
InventorsHoward Bregman, John Yeoman, Jennifer Downing, Samuel K. Reznik, Ernest Allen Sickmier, Giovanni Cianchetta, Rishi G. Vaswani, Neil Bifulco, Xia Tian, Andrew Tasker, Brian Hodous
Life of this patent
Estimating the term…
Abstract
The present disclosure relates generally to STAT6 modulators and uses thereof, and more specifically to compounds, salts, and compositions thereof useful for treating conditions associated with STAT6.
Claims50
A compound of Formula (I),
- or a pharmaceutically acceptable salt thereof, wherein:
- R1a and R1b are each independently H or halogen;
- R2 is H, (C1-C6)alkyl, or (C3-C6)cycloalkyl;
- R3 is (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C6)cycloalkyl, 3- to 7-membered heterocyclyl, —(C1-C6)alkylene-(C3-C6)cycloalkyl, or —(C1-C6)alkylene-(3- to 7-membered heterocyclyl), wherein (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl of —(C1-C6)alkylene-(C3-C6)cycloalkyl, or (3- to 7-membered heterocyclyl) of —(C1-C6)alkylene-(3- to 7-membered heterocyclyl) is each substituted with 0, 1, 2, 3, 4, or 5 substituents each independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkoxy, cyano, halogen, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy;
- R4 is H, (C6-C10)aryl, or 5- to 10-membered heteroaryl, wherein (C6-C10)aryl or 5- to 10-membered heteroaryl is each substituted with 0, 1, 2, or 3 substituents each independently selected from the group consisting of halogen, cyano, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, and —NR4aR4b, wherein:
- each R4a and R4b is independently H or (C1-C6)alkyl;
- R5 is H;
- RP is;
- RP1 and RP2 are each independently —OH, —ORPa, N-linked amino acid, N-linked amino acid ester, or
- wherein
- is substituted with 0, 1, 2, or 3 substituents each independently selected from the group consisting of halo, oxo, COOH, and —C(O)ORPE;
- each RPa is independently (C1-C6)alkyl, halo(C1-C6)alkyl, (C6-C10)aryl, or (C3-C6)cycloalkyl, wherein (C1-C6)alkyl is substituted with 0, 1, 2, or 3 substituents each independently selected from the group consisting of halo and (C1-C6)alkoxy;
- and
- each RPE is independently (C1-C6)alkyl, halo(C1-C6)alkyl, —(C1-C6)alkylene-(C1-C6)alkoxy, (C3-C6)cycloalkyl, (C5-C6)spirocycloalkyl, —(C1-C6)alkylene-(C6-C10)aryl, —(C1-C6)alkylene-(C3-C7)cycloalkyl, 3- to 7-membered heterocyclyl, or —(C1-C6)alkylene-(3- to 7-membered heterocyclyl), wherein (C1-C6)alkyl, (C3-C6)cycloalkyl, (C5-C8)spirocycloalkyl, or (C3-C7)cycloalkyl of —(C1-C6)alkylene-(C3-C7)cycloalkyl is each substituted with 0, 1, 2, or 3 independently selected halogen.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.