Oxygen-containing heterocyclic compound and use thereof

An oxygen-containing heterocyclic compound represented by Formula I, a pharmaceutically acceptable salt thereof, deuterated derivative thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof:

• wherein:
• Ar is C6-20 aryl, C6-20 aryl substituted with one or more R1-1, “5-12 membered heteroaryl containing 1-4 heteroatoms selected from O, S and N”, or “5-12 membered heteroaryl containing 1-4 heteroatoms selected from O, S and N” substituted with one or more R1-2;
• R1-1 and R1-2 are independently selected from halogen, hydroxyl and C1-6 alkyl;
• is a 5-6 membered heteroaryl containing 1-3 heteroatoms selected from O, S and N;
• R1 and R2 are independently selected from hydrogen, deuterium, hydroxyl, C1-6 alkyl, amino, and —OC1-6 alkyl;
• R3 and R4 are C1-6 alkyl substituted with deuterium, or, R3 and R4 together with the atom they are attached form C3-8 cycloalkyl, C3-8 cycloalkyl substituted with R1-3, 4- to 10-membered heterocycloalkyl containing 1-3 heteroatoms selected from O, S and N, “4- to 10-membered heterocycloalkyl containing 1-3 heteroatoms selected from O, S and N” substituted with R1-4, and
• R1-3 and R1-4 are independently selected from halogen, deuterium, hydroxyl and C1-6 alkyl.