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US 12,709,601 B2Granted
Radiolabelled compound
AssigneeOxford University Innovation Limited
InventorsVeronique Gouverneur, Bart Cornelissen, Thomas Charles Wilson
Life of this patent
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Abstract
The present invention relates to radiolabelled olaparib and in particular [18 F]olaparib, a process for producing radiolabelled olaparib, and uses of radiolabelled olaparib in medical imaging.
Claims11
A process for producing a compound of formula (I)
- which process comprises:
- (i) treating an organoboron compound of formula (II) with 18F− and a copper compound:
- wherein
- Z is a boronic ester group, a boronic acid group, a boronate group or a trifluoroborate group;
- and
- RP is a protecting group of formula (III)
- wherein
- R1 is C1-6 alkyl;
- R2 is C1-6 alkyl;
- and
- R3 is C1-6 alkyl;
- and
- (ii) removing the protecting group RP to produce the compound of formula (I).
10 more elements
Dependencies are inferred from the claim text.