Benzonitric heterocyclic compound, preparation method therefor and use thereof

A benzonitric heterocyclic compound represented by formula I-1 or a pharmaceutically acceptable salt thereof,

• X1 is
• R2 is independently hydrogen, hydroxyl, C1-C4 alkyl, C1-C4 alkyl-O—, (RaRb)N— or O═;
• R1a, R1b, R1c and R1d are independently hydrogen, halogen, hydroxyl, cyano or R1-L-;
• -L- is independently a linker bond, —(C1-C4 alkyl)-, —O—, —C(═O)— or —S(═O)2—;
• R1 is independently C1-C6 alkyl, C3-C7 cycloalkyl, C6-C10 aryl, (RcRd)N—, 3- to 7-membered heterocycloalkyl or 5- to 10-membered heteroaryl, or, the C1-C6 alkyl, C3-C7 cycloalkyl, C6-C10 aryl, (RcRd)N—, 3- to 7-membered heterocycloalkyl and 5- to 10-membered heteroaryl are substituted by one or more substituents of Re;
• in the 3- to 7-membered heterocycloalkyl and the 3- to 7-membered heterocycloalkyl substituted by one or more substituents of Re, the heteroatom is selected from one or more of N, O, S, S(═O) and S(═O)2, and the number of heteroatoms is 1 to 3;
• in the 5- to 10-membered heteroaryl and the 5- to 10-membered heteroaryl substituted by one or more substituents of Re, the heteroatom is selected from one or more of N, O and S, and the number of heteroatoms is 1 to 4;
• Re is independently hydroxyl, halogen, cyano or C1-C4 alkyl;
• when there are multiple substituents, they are the same or different;
• Ra, Rb, Rc and Rd are independently hydrogen or C1-C4 alkyl;
• R3a, R3b, R3c, R3d, R4 and R5 are independently hydrogen, halogen, C1-C4 alkyl or C1-C4 alkyl substituted by one or more halogen;
• when there are multiple substituents, they are the same or different;
• a carbon atom with “*” indicates that when it is a chiral carbon atom, it is a S configuration, R configuration or a mixture thereof.