Molecules

A compound of general formula:

• A-Y—B
• wherein A is represented by:
• wherein:
• b is 0;
• w is 1;
• v is an integer from 2 to 5;
• z is 1;
• X is —S—;
• Z1 and Z2 are each independently selected from the group consisting of —O—, —NR—, —S—, S(═O), S(═O)2—, —C(═O)O—, —OC(═O)—, —C(═O)NR—, —NRC(═O)—, —C(═O)S—, —SC(═O)—, OC(═O)O—, NRC(═O)O—, —OC(═O)NR—, and —NRC(═O)NR—;
• R11, R12, Rx, Ry, R14, R15, R16, and R17 are each independently H or C1-C6 aliphatic;
• R, R13 and R18 are each independently H or C1-C6 aliphatic;
• R19 is H, C1-C6 aliphatic, an amino protecting group, L3-C(═O)—, or A2;
• L1 and L2 are each independently C5-C21 aliphatic or C4-C20 heteroaliphatic;
• L3 is C1-C21 aliphatic or C2-C20 heteroaliphatic;
• A2 is an amino acid or a peptide;
• wherein any aliphatic or heteroaliphatic present in any of R, R11, R12, R13, R14, R15, R16, R17, R18, R19, Rx, Ry, L1, L2, and L3 is optionally substituted;
• Y is
• wherein:
• R1 and R2 are independently selected from the group consisting of H, —CH2OH, —CH2CH2OH, —CH(CH3)OH, —CH2OPO(OH)2, —CH2C(═O)NH2, —CH2CH2C(═O)OH and —CH2CH2C(═O)OR8, wherein any one of the alkyl hydrogens can be replaced with a halogen;
• R8 is selected from the group consisting of H and a straight or branched C1-C6 alkyl;
• and
• B represents a Polyethylene Glycol (PEG), wherein the PEG is a substituted PEG according to the following formula:
• wherein
• n is 3 to 100;
• m is 1, 2, 3, or 4;
• p is 2, 3, or 4;
• q is null or 1;
• R3 is H, —NH2, or —OH, wherein when q is null, R3 is H and when q is 1, R3 is —NH2 or —OH;
• L is null or consists of 1 to 10 units, wherein each unit has the formula:
• wherein
• R4 is H;
• and
• R5 is a side chain of an amino acid selected from:
• the 20 naturally occurring amino acids commonly designated by three letter symbols, 4-hydroxyproline, hydroxylysine, demosine, isodemosine, 3-methylhistidine, norvlin, beta-alanine, gamma-aminobutyric acid, citrulline, homocysteine, homoserine, ornithine, and methionine sulfone;
• or a pharmaceutically acceptable salt, solvate or prodrug thereof.