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US 12,708,864 B2Granted
Continuous liquid-liquid chromatographic separation of chemical species using multiple liquid phases and related systems and articles
AssigneeZaiput Flow Technologies LLC
InventorsLorenzo Milani, Trevor Charles Murray, Robert Viano, Andrea Adamo, Róbert Örkényi
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Abstract
The present disclosure is related to the continuous liquid-liquid chromatographic separation of chemical species using multiple liquid phases and related systems and articles.
Claims17
A method, comprising:
- transporting a feed liquid stream comprising a first solute and a second solute into a feed liquid inlet of a liquid-liquid chromatographic separator system, wherein the liquid-liquid chromatographic separator system comprises three or more separator stages arranged in series with one another from a first separator stage to a last separator stage, with one or more intermediate stages positioned between the first separator stage and the last separator stage;
- transporting a liquid comprising at least a portion of the first solute and at least a portion of the second solute into a first liquid inlet of a first separator stage, such that the first separator stage produces:
- a liquid having a mole fraction of the first solute relative to the sum of the first solute and the second solute that is larger than a mole fraction of the first solute relative to the sum of the first solute and the second solute in the liquid received by the first liquid inlet of the first separator stage, and
- a liquid having a mole fraction of the second solute relative to the sum of the first solute and the second solute that is larger than a mole fraction of the second solute relative to the sum of the first solute and the second solute in the feed liquid stream;
- and
- transporting a liquid comprising at least a portion of the first solute and at least a portion of the second solute into a last liquid inlet of the last separator stage, such that the last separator stage produces:
- a liquid having a mole fraction of the first solute relative to the sum of the first solute and the second solute that is larger than a mole fraction of the first solute relative to the sum of the first solute and the second solute in the feed liquid stream, and
- a liquid having a mole fraction of the second solute relative to sum of the first solute and the second solute that is larger than a mole fraction of the second solute relative to the sum of the first solute and the second solute in the liquid received by the last liquid inlet.
5 more elements
Dependencies are inferred from the claim text.