Membrane separation devices, systems and methods employing same, and data management systems and methods

A single pass method for collection and separation of whole blood from a donor into blood components employing an automated blood collection system comprising a donor access device and a blood separation device employing rotating surfaces, the single pass method comprising:

• a) preventing communication between the donor access device and the blood separation device by closing a first clamp upstream of an anticoagulant source and pump;
• b) priming the system with anticoagulant while the first clamp remains closed;
• performing a venipuncture on the donor with the donor access device;
• c) flowing whole blood from the donor after opening the first clamp to allow communication between the donor access device and the blood separation device;
• d) adding anticoagulant to the whole blood upstream of the blood separation device to obtain anticoagulated whole blood;
• e) flowing anticoagulated whole blood through a leukoreduction filter by exerting a draw force on the anticoagulated whole blood with a draw line pump located downstream from the leukoreduction filter and then to the blood separation device wherein the leukoreduction filter is located upstream of the blood separation device;
• f) separating the anticoagulated whole blood into substantially concentrated red blood cells and plasma;
• g) flowing plasma from the blood separation device to a first collection container and substantially concentrated red blood cells from the blood separation device to a second collection container;
• h) continuing steps c)-g) until a volume of red blood cells in the second collection container reaches a predetermined volume;
• i) removing the donor access device from the donor upon the collection of the predetermined volume of red blood cells;
• and
• j) rinsing the system with anticoagulant and exhausting the anticoagulant used for rinsing into the second collection container;
• wherein the method is performed with only a single pass of the anticoagulated whole blood through the blood separation device and without reinfusion of blood components to the donor.