Back to results
US 12,708,680 B2Granted
Selective acoustic disruption of pathogens
AssigneeNopioid, LLC
InventorsPeter Donald Haaland, Howland Shaw Warren
Life of this patent
Estimating the term…
Abstract
Described herein are methods and devices for selectively diminishing viability of or killing bacterial, fungal, or viral pathogens using acoustic excitation below the thresholds for cavitation.
Claims25
A method for selectively killing or diminishing viability of a pathogen infecting a mammalian subject tissue, the method comprising:
- contacting a mammalian subject tissue with one or more acoustic transducers;
- and
- administering greater than ten thousand cycles of pressure variation below a threshold for cavitation of the mammalian subject tissue, whereby the greater than ten thousand cycles of pressure variation is sufficient to kill or diminish viability of a pathogen infecting the mammalian subject tissue without harming the mammalian subject tissue;
- with the proviso that the only form of energy administered to kill or diminish the viability of the pathogen is acoustic energy.
1 more element
A method for treating a mammalian subject infected by one or more pathogens using an acoustic transducer to selectively kill or diminish viability of the one or more pathogens, the method comprising:
- contacting the acoustic transducer to an external surface of the mammalian subject such that the acoustic transducer conforms to the external surface, the acoustic transducer being a conformable piezoelectric transducer array, comprising:
- a silicone elastomer substrate and a silicone elastomer superstrate;
- a plurality of piezoelectric transducer elements disposed between the silicone elastomer substrate and silicone elastomer superstrate;
- a first electrical interconnect layer electrically interconnecting a first surface of the plurality of piezoelectric transducer elements adjacent to the silicone elastomer substrate;
- and
- a second electrical interconnect layer electrically interconnecting a second surface of the plurality of piezoelectric transducer elements adjacent to the silicone elastomer superstrate;
- and
- administering greater than ten thousand cycles of pressure variation below a threshold for cavitation of the mammalian subject, whereby the greater than ten thousand cycles of pressure variation is sufficient to kill or diminish viability of the one or more pathogens infecting the mammalian subject without harming the mammalian subject;
- with the proviso that the only form of energy administered to kill or diminish the viability of the one or more pathogens is acoustic energy.
6 more elements
Dependencies are inferred from the claim text.