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US 12,708,663 B2Granted
Influenza virus encoding a truncated NS1 protein and a SARS-CoV receptor binding domain
AssigneeVivaldi Biosciences Inc.
InventorsAmy Aspelund, Thomas Muster, Markus Wolschek
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Abstract
The present invention refers to a recombinant influenza vims encoding a fusion protein comprising a truncated NS1 protein and a SARS-CoV receptor binding domain, specifically a SARS-CoV-2 RBD, and its use for prophylactic treatment, a pharmaceutical preparation comprising said virus for use in prime boost vaccination and a two-component vaccine for prime boost vaccination.
Claims20
A recombinant influenza virus comprising a modified NS segment, encoding:
- a) a fusion protein comprising from N to C-terminus:
- a truncated NS1 protein consisting of 10 to 20 amino acids of the N-terminus of the respective wild type NS1 protein,
- optionally a linker sequence,
- optionally a 2A self-cleaving peptide, specifically a P2A sequence,
- a signal peptide,
- a SARS-COV receptor binding domain (RBD) comprising up to 40, up to 30, or up to 27 amino acids of the C-terminal of the SARS-COV S1 subunit, and
- b) an NS2 protein.
4 more elements
Dependencies are inferred from the claim text.