Monoclonal antibody against human activated protein C and preparation and use thereof

An anti-activated protein C (aPC) monoclonal antibody, wherein the anti-aPC monoclonal antibody is selected from one of the following:

• an antibody comprising (a) heavy chain CDRs represented by SEQ ID NOs:
• 33, 34, and 35;
• and (b) light chain CDRs represented by SEQ ID NOs:
• 36, 37, and 38;
• an antibody comprising (c) heavy chain CDRs represented by SEQ ID NOs:
• 39, 40, and 41;
• and (d) light chain CDRs represented by SEQ ID NOs:
• 42, 43, and 44;
• an antibody comprising (e) heavy chain CDRs represented by SEQ ID NOs:
• 45, 46, and 47;
• and (f) light chain CDRs represented by SEQ ID NOs:
• 48, 49, and 50;
• an antibody comprising (g) heavy chain CDRs represented by SEQ ID NOs:
• 51, 52, and 53;
• and (h) light chain CDRs represented by SEQ ID NOs:
• 54, 55, and 56;
• an antibody comprising (i) heavy chain CDRs represented by SEQ ID NOs:
• 57, 58, and 59;
• and (i) light chain CDRs represented by SEQ ID NOs:
• 60, 61, and 62;
• an antibody comprising (k) heavy chain CDRs represented by SEQ ID NOS:
• 63, 64, and 65;
• and (l) light chain CDRs represented by SEQ ID NOs:
• 66, 67, and 68;
• an antibody comprising (m) heavy chain CDRs represented by SEQ ID NOs:
• 69, 70, and 71;
• and (n) light chain CDRs represented by SEQ ID NOs:
• 72, 73, and 74;
• an antibody comprising (o) heavy chain CDRs represented by SEQ ID NOs:
• 75, 76, and 77;
• and (p) light chain CDRs represented by SEQ ID NOs:
• 78, 79, and 80;
• an antibody comprising (q) heavy chain CDRs represented by SEQ ID NOs:
• 81, 82, and 83;
• and (r) light chain CDRs represented by SEQ ID NOs:
• 84, 85, and 86;
• and
• an antibody comprising (s) heavy chain CDRs represented by SEQ ID NOs:
• 87, 88, and 89;
• and (t) light chain CDRs represented by SEQ ID NOs:
• 90, 91, and 92.