Botanicals as WNT/beta-catenin activators, molecular pathway regulators, tissue regenerators and health biomarker regulators

Abstract

The present disclosure provides botanicals and/or biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wat/β-Catenin signaling and thus treat or prevent diseases related to signal transduction. In particular, the disclosure provides Botanicals and Biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wnt/β-Catenin signaling in tissues expressing WntlOB including, adipose, adrenal, artery, blood, bone marrow, brain, breast, cervix, colon, esophagus, heart, intestine, kidney, liver, lung, muscle, ovary, pituitary, prostate, skin, spleen, testis, thyroid, uterus and vagina. The present compositions and methods are particularly suited to growing and melanizing hair.

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