Back to results
US 12,708,654 B2Granted
Virus particles for therapeutic purposes
AssigneeAbalos Therapeutics GmbH
InventorsJorg Vollmer, Marcus Kostka, Philipp Lang, Haifeng Xu
Life of this patent
Estimating the term…
Abstract
The invention relates to a virus particle comprising a lymphocytic choriomeningitis virus (LCMV) S segment and an LCMV L segment, wherein the S segment comprises an open reading frame encoding a glycoprotein derived from LCMV strain WE, and wherein the L segment comprises an open reading frame encoding an L protein derived from LCMV strain Clone13. The invention also relates to related host cells, methods of producing such virus particles, pharmaceutical compositions comprising such virus particles, and medical uses of such virus particles.
Claims10
A virus particle comprising:
- a lymphocytic choriomeningitis virus (LCMV) S segment nucleic acid comprising an open reading frame encoding an LCMV glycoprotein having at least 99% sequence identity to SEQ ID NO:
- 14, and an open reading frame encoding an LCMV nucleoprotein having at least 99% sequence identity to SEQ ID NO:
- 6, wherein the open reading frame encoding the LCMV glycoprotein encodes a tryptophan at residue 185 and a methionine at residue 181 of the LCMV glycoprotein;
- and
- an LCMV L segment nucleic acid comprising an open reading frame encoding an LCMV L protein of SEQ ID NO:
- 40, and an open reading frame encoding an LCMV Z protein of SEQ ID NO:
- 38.
4 more elements
Dependencies are inferred from the claim text.