Treatment using cytokine encoding RNA
AssigneesBioNTech SE, TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gemeinnützige GmbH
InventorsUgur Sahin, Lena Kranz, Mathias Vormehr, Mustafa Diken, Sebastian Kreiter, Bodo Tillmann
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Abstract
The present disclosure relates to methods and compositions for inducing an immune response in a subject comprising co-administering to the subject RNA encoding peptides or proteins used for vaccination and RNA encoding IL-2 attached to a pharmacokinetic modifying group and/or RNA encoding IL-7 attached to a pharmacokinetic modifying group. The vaccine is particularly effective if an immune checkpoint inhibitor such as an anti-PD-L1 antibody is further administered. The present disclosure further relates to methods involving the target-specific delivery of a cytokine to a target organ or target tissue.
Claims35
A method for inducing an immune response against an antigen in a subject comprising administering to the subject:
- a. RNA encoding IL-2 attached to a moiety selected from the group consisting of serum albumin, an immunoglobulin Fc domain, transferrin, and Fn3 (extended pharmacokinetic (PK) IL-2) and RNA encoding extended IL-7 attached to a moiety selected from the group consisting of serum albumin, an immunoglobulin Fc domain, transferrin, and Fn3 (extended pharmacokinetic (PK) IL-7);
- and
- b. RNA encoding a peptide or protein comprising an epitope for inducing said immune response against said antigen in said subject.
A medical preparation comprising:
- a. RNA encoding IL-2 attached to a moiety selected from the group consisting of serum albumin, an immunoglobulin Fc domain, transferrin, and Fn3 (extended-pharmacokinetic (PK) IL-2) and RNA encoding IL-7 attached to a moiety selected from the group consisting of serum albumin, an immunoglobulin Fc domain, transferrin, and Fn3 (extended-pharmacokinetic (PK) IL-7);
- and
- b. RNA encoding a peptide or protein comprising an epitope for inducing an immune response against an antigen in a subject.
Dependencies are inferred from the claim text.