Immunogenic compositions containing N-glycolylneuraminic acid bearing nanoparticles
AssigneeRamot at Tel-Aviv University Ltd.
InventorsVered Padler-Karavani, Eliran Moshe Reuven, Shani Leviatan Ben-Arye
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Abstract
The present invention provides an active cancer vaccine and specifically an immunogenic compositions of membrane vesicles that serve as biomimetic nanoparticles derived from eukaryotic cell membranes that bear N-glycolylneuraminic acid glycoconjugates. These compositions can elicit beneficial immunological responses for treatment of Neu5Gc-positive tumors. The present invention provides methods of generating and using Neu5Gc-conjugated nanoparticles from eukaryotic cells membranes designated nano-ghosts.
Claims12
An immunogenic composition comprising a plurality of membrane vesicles bearing N-glycolylneuraminic acid (Neu5Gc) glycoconjugates;
- wherein the Neu5Gc glycoconjugates are exposed on the outer surface of the membrane vesicles;
- wherein said membrane vesicles are cell ghosts derived from the outer plasma membrane of a porcine Ggta1−/− red blood cell expressing Neu5Gc;
- and
- wherein the membrane vesicles have an average hydrodynamic diameter in the submicron range.
Dependencies are inferred from the claim text.