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AssigneeDongguk University Industry-Academic Cooperation Foundation
InventorsHan Seok Choi, Yun Sung Lim, Kwang Joon Kim
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The present invention relates to a pharmaceutical composition for improving or treating hypoparathyroidism caused by damage to parathyroid tissue and vascular tissue around the parathyroid gland due to surgery around the neck, and a method for treating post-surgical hypoparathyroidism using the same, and the composition can promote secretion of parathyroid hormone by containing a calcium-sensing receptor antagonist as an active ingredient to help the restoration of damaged parathyroid tissue through neovascularization and angiogenesis, and furthermore, can alleviate hypocalcemia, hyperphosphatemia, and hypercalciuria by increasing the concentration of blood parathyroid hormone to a normal range level. Administration of the composition can improve the quality of life of patients with hypoparathyroidism.
A method for promoting the engraftment of transplanted parathyroid tissues through neovascularization and angiogenesis in a mammal in need of functional restoration of a damaged parathyroid gland, the method comprising administering to the mammal a composition comprising a calcium-sensing receptor antagonist compound of Formula 1:
Dependencies are inferred from the claim text.