Pharmaceutical composite formulation comprising proton pump inhibitor and antacid, and method for preparing same

A pharmaceutical composite formulation comprising:

• a first layer comprising, as an active ingredient, a proton pump inhibitor or a pharmaceutically acceptable salt thereof, a lubricant, and a binder;
• and
• a second layer comprising, as an active ingredient, an antacid that is magnesium hydroxide,
• wherein the proton pump inhibitor or a pharmaceutically acceptable salt thereof is esomeprazole or a pharmaceutically acceptable salt thereof,
• wherein the lubricant in the first layer is sodium stearyl fumarate, wherein the lubricant is comprised in an amount of 3.7 percent by weight (wt %) to 5.5 wt % based on the total weight of the first layer,
• wherein the binder is hydroxypropyl cellulose, wherein the binder is comprised in an amount of 1 wt % to 20 wt % based on the total weight of the first layer,
• wherein the first layer comprising the proton pump inhibitor or a pharmaceutically acceptable salt thereof, the lubricant, and the binder is in a form of granules, and
• wherein when a total weight of the first layer is 1 part by weight, a total weight of the second layer is 1.58 to 3.2 parts by weight.