Method of administering a hormone encapsulated by a hydrogel with a dual chamber syringe

A method for administering a hormone encapsulated by a hydrogel polymer with a dual chamber syringe, the method comprising:

• providing a crosslinked methacrylate hyaluronic acid (MHA) polymer that encapsulates the hormone in the form of a plurality of hydrogel microparticles, wherein the crosslinked MHA polymer is the hydrogel polymer, wherein the hormone is selected from the group consisting of testosterone, estradiol, and the combination thereof;
• administering a dosage of the crosslinked MHA polymer that encapsulates the hormone as the plurality of hydrogel microparticles to a subcutaneous tissue with a dual chamber syringe,
• wherein the dual chamber syringe includes,
• a first chamber that includes the crosslinked MHA polymer that encapsulates the hormone,
• a second chamber having a diluent,
• a separator that separates the first chamber from the second chamber when the separator is in a first position,
• a bypass that connects the first chamber to the second chamber when the separator is in a second position, wherein moving the separator from the first position to the second position generates a mixture that includes the diluent and the crosslinked MHA polymer that encapsulates the hormone, and
• a plunger that forces the mixture through a needle;
• and
• wherein the plurality of hydrogel microparticles are formulated to provide controlled release of the hormone over a period of at least one (1) week.