Systems, devices, components and methods for high resolution electrographic flow (EGF) mapping and analysis

A method of detecting at least one location of at least one intracardiac source or rotational phenomenon and/or at least one intracardiac zone or area of slow electrical conduction velocity, such source, phenomenon, zone or area being associated with at least one cardiac rhythm disorder in a patient's heart, the system comprising at least one computing device, at least one data acquisition device operably connected to the at least one computing device or configured to provide as outputs therefrom at least one of intracardiac electrophysiological EP mapping signals and/or body surface electrophysiological EP mapping signals (EP mapping signals), a display or monitor operably connected to the at least one computing device and configured to visually display to the user one or more maps generated by the at least one computing device, wherein the computing device comprises at least one non-transitory computer readable medium configured to store instructions executable by at least one processor to determine the at least one location of the at least one source, rotational phenomenon, and zone of slow electrical conduction associated with the at least one cardiac rhythm disorder in the patient's heart, the computing device being configured to:

• (i) receive the EP mapping signals from at least one of a plurality of intracardiac electrodes located inside the patient's heart and/or the body surface electrodes located on the surface of the patient's body (electrodes), the electrodes having spatial 2D and/or 3D positions on or in the patient's body associated therewith;
• (ii) preprocess the EP mapping signals;
• (iii) analyze the preprocessed EP mapping signals and determining reconstruction constraint parameters to apply thereto;
• (iv) apply the reconstruction constraint parameters to the EP mapping data and generate, using one or more correlation matrices, reconstructed EP mapping signals having spatial positions associated therewith and located between, or not at the same locations as, the spatial positions of the electrodes;
• (v) assign or relate positional data corresponding to spatial positions of:
• (a) the electrodes and their associated EP mapping signals, and (b) the reconstructed EP mapping signals;
• (vi) generate at least one spatial map of the electrode positions and the positions of the reconstructed EP mapping signals;
• (vii) for each or selected discrete times over which the EP mapping signals and the reconstructed EP mapping signals are being processed, process the EP mapping signals and the reconstructed EP mapping signals to generate a plurality of surfaces or data grids, each such surface or data grid corresponding at least partially to the at least one spatial map, at least one surface or data grid being generated for each such time, and (viii) using a multi-frame Horn-Schunck algorithm to process the plurality of surfaces or data grids through time to generate at least one enhanced resolution map corresponding at least partially to the spatial map, the at least one enhanced resolution map being configured to reveal the at least one location of the at least one source or rotational phenomenon or at least one zone or area of slow electrical conduction velocity associated with the at least one cardiac rhythm disorder, the at least one enhanced resolution map being shown to the user on the display or monitor, the method comprising:
• (a) acquiring, using the data acquisition device, the EP mapping signals;
• (b) using the computing device, assigning positions or identifiers for the electrodes and the reconstructed EP mapping signals;
• (d) using the computing device and the assigned positions or identifiers, providing or generating a spatial map of the intracardiac electrode and reconstructed EP mapping signal positions;
• (e) using the computing device, for each or selected discrete times over which the EP mapping signals are being processed, processing the EP mapping signals to generate a plurality of surfaces or data grids corresponding at least partially to the spatial map, one surface or data grid being generated for each such time, and (f) using the computing device to process the plurality of surfaces or data grids through time to generate an enhanced resolution map corresponding at least partially to the spatial map, the enhanced resolution map being configured to reveal on the monitor or display to a user the at least one location of the at least one source, phenomenon, zone or area associated with the at least one cardiac rhythm disorder.