Methods and compositions for treating cancer with von Willebrand factor peptide linked to immunotherapeutic antibodies
AssigneeThe University of Chicago
InventorsJeffrey A. Hubbell, Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Melody Swartz
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Abstract
The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
Claims20
A composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide, wherein the ECM-affinity peptide comprises a von Willebrand factor (VWF) peptide.
A composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide, wherein the ECM-affinity peptide comprises a von Willebrand factor (VWF) peptide, and wherein the VWF peptide comprises a peptide that is at least 85% identical to SEQ ID NO:3, SEQ ID NO:11, SEQ ID NO:
- 14, or fragments thereof.
Dependencies are inferred from the claim text.