Automated evaluation of human embryos
AssigneesThe Brigham and Women's Hospital, Inc., The General Hospital Corporation
InventorsHadi Shafiee, Charles Bormann, Manoj Kumar Kanakasabapathy, Prudhvi Thirumalaraju
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Abstract
Systems and methods are provided for provided for automatic evaluation of a human embryo. An image of the embryo is obtained and provided to a neural network to generate a plurality of values representing the morphology of the embryo. The plurality of values representing the morphology of the embryo are evaluated at an expert system to provide an output class representing one of a current quality of the embryo, a future quality of the embryo, a likelihood that implantation of the embryo will be successful, and a likelihood that implantation of the embryo will result in a live birth.
Claims20
A method for automatic evaluation of a human embryo, comprising:
- receiving an image of the embryo at a fully-automated computing system;
- generating a plurality of values at the fully-automated computing system, each of the plurality of values representing one of a shape, structure, and texture of the embryo;
- evaluating the plurality of values at the fully-automated computing system to provide an output representing one of a current quality of the embryo, a future quality of the embryo, a likelihood that implantation of the embryo will be successful, and a likelihood that implantation of the embryo will result in a live birth.
A fully-automated system for automatic evaluation of a human embryo comprising:
- a processor configured to:
- receive an image of the embryo;
- generate a plurality of values representing one of a shape, structure, and texture of the embryo from the image of the embryo;
- and
- provide an output representing one of (a) a future quality of the embryo, (b) a likelihood of the embryo's viability upon implantation, or (c) a likelihood that implantation of the embryo will result in a live birth, wherein the processor is trained to evaluate the plurality of values representing the morphology of a embryo and provide the likelihood based on evaluation of the plurality of values.
A fully-automated system for automatic evaluation of a human embryo comprising:
- a processor configured to:
- receive an image of the embryo;
- generate a plurality of values representing one of a shape, structure, and texture of the embryo from the image of the embryo at an expert system being trained on training images of embryos labeled with corresponding output values by a human expert;
- and
- provide an output representing one of (a) a future quality of the embryo, (b) a likelihood of the embryo's viability upon implantation, or (c) a likelihood that implantation of the embryo will result in a live birth, wherein the processor is trained to evaluate the plurality of values representing a morphology of the embryo and provide the likelihood based on evaluation of the plurality of values.
Dependencies are inferred from the claim text.