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US 12,704,521 B2Granted
On-site rapid quantification of tetrahydrocannabinol
AssigneesThe General Hospital Corporation, Industry-Academic Cooperation Foundation, Yonsei University, Institute for Basic Science
InventorsHakho Lee, Ralph Weissleder, Hojeong Yu, Jinwoo Cheon
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Abstract
Aspects of the present disclosure provide devices and methods for rapid, quantitative, on-site detection of controlled substances. Devices include a sample processing module and a sensor cartridge, and optionally a detection cradle.
Claims27
A device for detecting a controlled substance, the device comprising:
- (a) a sample processing module comprising:
- a metering reservoir reversibly connected to a sample chamber, an air chamber, and a loading chamber via a first fluidic channel, a second fluidic channel, and a third fluidic channel, respectively,
- wherein the metering reservoir is reversibly connected to a waste chamber via a syphon that is configured to actuate upon a predetermined volume of liquid being received in the metering reservoir,
- wherein the loading chamber comprises a detection probe that binds a controlled substance, and wherein the loading chamber is connected to a fourth fluidic channel comprising one or more openings;
- (b) a sensor cartridge comprising:
- a control membrane aligned to the control sample outlet and comprising a loading control probe that binds to the detection probe, and
- a test membrane aligned to the test sample outlet and comprising a capture probe comprising the controlled substance;
- and
- (c) a first cap having a protrusion that forms a piston relative to the sample chamber when the first cap is joined to the sample chamber, and a second cap having a protrusion that forms a piston relative to the air chamber when the second cap is joined to the air chamber.
6 more elements
Dependencies are inferred from the claim text.