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AssigneesThe Board of Trustees of the University of Illinois, Universidad Nacional De La Plata, Consejo Nacional De Investigaciones Cientificas Y Tecnicas
InventorsYi Lu, Ana Sol Peinetti, Omar Azzaroni
Estimating the term…
Methods of detecting presence of a virus in a sample are provided, the method including contacting the sample with a solid state nanopore comprising a plurality of virus-specific aptamers and measuring a current-voltage curve in the solid state nanopore, wherein a decrease in the current indicates presence of the virus in the sample. Solid state nanopores comprising a plurality of virus-specific aptamers covalently linked to the interior of the solid state nanopore are also provided. Membranes including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers and kits and systems with a membrane including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers are also provided.
A method of detecting presence of a virus particle in a sample, comprising:
A solid state nanopore comprising a plurality of virus-specific aptamers covalently linked to an inner wall of the solid state nanopore, wherein the solid state nanopore passes from a first surface to a second surface of a membrane and wherein the solid state nanopore comprises a diameter of about 50-60 nm at the first surface of the membrane and a diameter of about 800-1000 nm at the second surface of the membrane.
Dependencies are inferred from the claim text.