Mass spectrometry system, processing device, and anomaly detection method

A processing device configured to acquire a signal intensity that is a measurement result of a substance from a mass spectrometer of a liquid chromatograph mass spectrometer including a liquid chromatography including a plurality of flow paths and the mass spectrometer,

• wherein
• each of the plurality of flow paths is provided with a separation column and the plurality of flow paths is installed so as to be parallel to each other,
• the processing device is configured to control a selector valve to select a flow path connected to the mass spectrometer from the plurality of flow paths,
• the processing device is configured to cause a predetermined substance to flow together with a solution in each of the plurality of flow paths, and the mass spectrometer is configured to measure the predetermined substance,
• the processing device is configured to determine anomaly of the liquid chromatography and the mass spectrometer based on the signal intensity obtained as a result of measurement of the predetermined substance by the mass spectrometer for each of the plurality of flow paths, and is configured to output a result of determination to an output unit,
• the predetermined substance is a mixed sample including a plurality of components having different ionization efficiencies, and
• the processing device is configured to calculate a signal intensity ratio for each of the flow paths, the signal intensity ratio being a ratio of signal intensities of the mixed sample, and is configured to determine an anomaly of the liquid chromatography and the mass spectrometer based on the signal intensity and the signal intensity ratio in each of the flow paths.

An anomaly detection method in a mass spectrometry system including a liquid chromatography including a plurality of flow paths, a mass spectrometer, and a processing device configured to acquire a signal intensity that is a measurement result of a substance from the mass spectrometer,

• wherein each of the plurality of flow paths is provided with a separation column and the plurality of flow paths is installed so as to be parallel to each other,
• the method comprising the steps of:
• controlling, by the processing device, a selector valve to select a flow path connected to the mass spectrometer is selected from the plurality of flow paths,
• causing, by the processing device, a predetermined substance to flow together with a solution in each of the plurality of flow paths, and measuring, by the mass spectrometer, the predetermined substance, and
• determining, by the processing device, an anomaly of the liquid chromatography and the mass spectrometer based on the signal intensity obtained as a result of measurement of the predetermined substance by the mass spectrometer for each of the plurality of flow paths, and outputting, by the processing device, a result of determination to an output unit,
• wherein the predetermined substance is a mixed sample including a plurality of components having different ionization efficiencies, and
• wherein the method further comprises:
• calculating, by the processing device, a signal intensity ratio for each of the flow paths, the signal intensity ratio being a ratio of signal intensities of the mixed sample, and determining an anomaly of the liquid chromatography and the mass spectrometer based on the signal intensity and the signal intensity ratio in each of the flow paths.