Method of detecting the presence of a pathogen in a biological liquid

A method for detecting SARS-CoV-2 in at least one surface enhanced Raman spectroscopy (SERS) signal obtained from a sample brought into contact with non-magnetic native metal nanoparticles, the method being implemented by a computer and comprising:

• a reception of each surface enhanced Raman spectroscopy (SERS) signal obtained from the sample brought into contact with the non-magnetic native metal nanoparticles;
• an implementation of a classification model configured to associate each surface enhanced Raman spectroscopy signal received with at least one class representative of a presence or absence of the pathogen in the sample,
• wherein the classification model is configured to apply at least one treatment relating to at least three peaks in the surface enhanced Raman spectroscopy signal among:
• a peak at a Raman offset between 419 cm−1 and 459 cm−1, or
• a peak at a Raman offset between 566 cm−1 and 606 cm−1, or
• a peak at a Raman offset between 646 cm−1 and 686 cm−1, or
• a peak at a Raman offset between 719 cm−1 and 759 cm−1, or
• a peak at a Raman offset between 839 cm−1 and 879 cm−1, or
• a peak at a Raman offset between 962 cm−1 and 1002 cm−1, or
• a peak at a Raman offset between 1006 cm−1 and 1046 cm−1, or
• a peak at a Raman offset between 1121 cm−1 and 1161 cm−1, or
• a peak at a Raman offset between 1190 cm−1 and 1230 cm−1, or
• a peak at a Raman offset between 1339 cm−1 and 1379 cm−1, or
• a peak at a Raman offset between 1529 cm−1 and 1569 cm−1, or
• a peak at a Raman offset between 1591 cm−1 and 1631 cm−1, or
• a peak at a Raman offset between 1662 cm−1 and 1702 cm−1, or
• a peak at a Raman offset between 1722 cm−1 and 1762 cm−1, or
• a peak at a Raman offset between 1796 cm−1 and 1836 cm−1, or
• a peak at a Raman offset between 2058 cm−1 and 2098 cm−1, or
• a peak at a Raman offset between 2110 cm−1 and 2150 cm−1, or
• a peak at a Raman offset between 2322 cm−1 and 2362 cm−1, or
• a peak at a Raman offset between 2460 cm−1 and 2500 cm−1.