Method of producing and refining carrier-free lutetium-177 using chromatography
AssigneeKorea Atomic Energy Research Institute
InventorsKang Hyuk Choi, Ul Jae Park, Jun Sig Lee, A Ran Kim
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Abstract
The present invention relates to a method of producing and refining carrier-free lutetium-177 using chromatography, and more specifically to a method of producing and refining carrier-free lutetium 1-77 using chromatography having excellent resolution of lutetium and ytterbium without a concentration gradient of an eluent.
Claims13
A method for separating carrier-free lutetium-177 (Lu-177), which sequentially performs chromatography for a mixture comprising a compound of ytterbium and lutetium-177 (Lu-177) produced by irradiating neutrons at a compound of ytterbium-176 (Yb-176) as a target by 2 columns below:
- 1) separation column:
- a separation column with a cation exchange resin as a stationary phase, the separation column being filled with the stationary phase and being saturated with a first eluent comprising primary aminium ions and a chelating agent, and the first eluent being used as a mobile phase in the separation column;
- and
- 2) purification column:
- a purification column with the cation exchange resin as a stationary phase, and impregnated with water, wherein the first eluent is introduced from the separation column into the purification column
- wherein the first eluent is a single eluent without a concentration gradient.
Dependencies are inferred from the claim text.