Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

An artificial expression construct comprising

• (i) an enhancer consisting of
• the sequence of SEQ ID NO:
• 29,
• the sequence of SEQ ID NO:
• 177,
• the sequence of SEQ ID NO:
• 178,
• the sequence of SEQ ID NO:
• 188,
• the sequence of SEQ ID NO:
• 25,
• the sequence of SEQ ID NO:
• 26,
• the sequence of SEQ ID NO:
• 27,
• the sequence of SEQ ID NO:
• 28,
• the sequence of SEQ ID NO:
• 31,
• the sequence of SEQ ID NO:
• 32,
• the sequence of SEQ ID NO:
• 33,
• the sequence of SEQ ID NO:
• 34,
• the sequence of SEQ ID NO:
• 35,
• the sequence of SEQ ID NO:
• 36,
• the sequence of SEQ ID NO:
• 37,
• the sequence of SEQ ID NO:
• 38,
• the sequence of SEQ ID NO:
• 39,
• the sequence of SEQ ID NO:
• 41,
• the sequence of SEQ ID NO:
• 42,
• the sequence of SEQ ID NO:
• 43,
• the sequence of SEQ ID NO:
• 44,
• the sequence of SEQ ID NO:
• 45,
• the sequence of SEQ ID NO:
• 46,
• the sequence of SEQ ID NO:
• 47,
• the sequence of SEQ ID NO:
• 48,
• the sequence of SEQ ID NO:
• 50,
• the sequence of SEQ ID NO:
• 51,
• a sequence having at least 95% sequence identity to the sequence consisting of SEQ ID NO:
• 29,
• a sequence having at least 95% sequence identity to the sequence consisting of SEQ ID NO:
• 177,
• a sequence having at least 95% sequence identity to the sequence consisting of SEQ ID NO:
• 178,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 188,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 25,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 26,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 27,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 28,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 31,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 32,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 33,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 34,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 35,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 36,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 37,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 38,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 39,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 41,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 42,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 43,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 44,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 45,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 46,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 47,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 48,
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 50, or
• a sequence having at least 95% sequence identity with the sequence consisting of SEQ ID NO:
• 51,
• (ii) a promoter, and
• (iii) a coding sequence.