Back to results
US 12,703,865 B2Granted
Small interfering RNA targeting C3 and uses thereof
AssigneeSanegene Bio USA Inc.
InventorsChunyang Zhang, Xin Geng, Shiyu Wang, Weimin Wang
Life of this patent
Estimating the term…
Abstract
This disclosure relates to isolated oligonucleotides comprising duplex regions targeting human complement C3 mRNA, and delivery systems, kits and compositions comprising the same, and methods of using the same for inhibiting or downregulating C3 gene expression.
Claims9
An isolated oligonucleotide comprising:
- an antisense strand comprising the nucleic acid sequence 5′
- [mUs][fUs][fA][mG][fU][mA][fG][mA][mA][fU][mU][mU][mC][fU][mC][fU][mG][mU][mA][mGs][mGs][mC] 3′ (SEQ ID NO:
- 451), and
- a sense strand comprising the nucleic acid sequence 5′
- [mCs][mUs][mA][mC][mA][fG][mA][fG][fA][fA][fA][mU][mU][mC][mU][mA][mC][mUs][mAs][mA][G1b][G1b][G1b] 3′ (SEQ ID NO:
- 444),
- wherein “m” is a 2′-O-methyl modification, “f” is a 2′-F modification, “s” is a phosphorothioate internucleotide linkage, and “G1b” is a GalNAc G1b moiety.
4 more elements
An isolated oligonucleotide comprising an antisense strand and a sense strand:
- the antisense strand consisting of the nucleic acid sequence 5′ [mUs][fUs][fA][mG][fU][mA][fG][mA][mA][fU][mU][mU][mC][fU][mC][fU][mG][mU][mA][mGs][mGs][mC] 3′ (SEQ ID NO:
- 451), and
- the sense strand consisting of the nucleic acid sequence 5′
- [mCs][mUs][mA][mC][mA][fG][mA][fG][fA][fA][fA][mU][mU][mC][mU][mA][mC][mUs][mAs][mA][G1b][G1b][G1b] 3′ (SEQ ID NO:
- 444),
- wherein “m” is a 2′-O-methyl modification, “f” is a 2′-F modification, “s” is a phosphorothioate internucleotide linkage, and “G1b” is a GalNAc G1b moiety.
3 more elements
An isolated oligonucleotide consisting of an antisense strand and a sense strand:
- the antisense strand consisting of the nucleic acid sequence 5′
- [mUs][fUs][fA][mG][fU][mA][fG][mA][mA][fU][mU][mU][mC][fU][mC][fU][mG][mU][mA][mGs][mGs][mC] 3′ (SEQ ID NO:
- 451), and
- the sense strand consisting of the nucleic acid sequence 5′
- [mCs][mUs][mA][mC][mA][fG][mA][fG][fA][fA][fA][mU][mU][mC][mU][mA][mC][mUs][mAs][mA][G1b][G1b][G1b] 3′ (SEQ ID NO:
- 444),
- wherein “m” is a 2′-O-methyl modification, “f” is a 2′-F modification, “s” is a phosphorothioate internucleotide linkage, and “G1b” is a GalNAc G1b moiety.
4 more elements
Dependencies are inferred from the claim text.