Methods of treating diseases associated with elevated uric acid
AssigneeProtalix Ltd.
InventorsIlya Ruderfer, Yakir Nataf, Gil Arvatz, Uri Hanania, Tamar Ariel, Shelly Rozen, Yael Hayon, Zohar Keren, Orit Cohen-Barak
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Abstract
A method of treating a disease or disorder associated with excessive uric acid levels is disclosed herein. The method comprises administering to the subject by i.v. infusion an amount of a recombinant homotetrameric uricase enzyme comprising four uricase polypeptides having the amino acid sequence as set forth in SEQ ID NO: 2, wherein the polypeptides are crosslinked by polyethylene glycol (PEG) bis-aldehyde having a molecular weight of 2-3.5 kDa.
Claims13
A method of treating gout in a subject in need thereof, comprising administering to the subject by i.v. infusion an amount of a recombinant homotetrameric uricase enzyme comprising four uricase polypeptides having the amino acid sequence as set forth in SEQ ID NO:
- 2, wherein said polypeptides are crosslinked by polyethylene glycol (PEG) bis-aldehyde having a molecular weight of 2-3.5 kDa, wherein said administering is no more than once every four weeks, wherein said amount is 36 mg per subject.
Dependencies are inferred from the claim text.