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US 12,703,849 B2Granted
Therapeutic engineered microbial cell system and methods for treating hyperuricemia and gout
AssigneeUnlocked Labs
InventorChristoph Geisler
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Abstract
The present disclosure relates to engineered microbial cells that have been engineered to include a uricase, a uric acid transporter, or both a uricase and a uric acid transporter. The engineered microbial cells of the present disclosure are useful in degrading uric acid inside the engineered microbial cell. The engineered microbial cells of the present disclosure are useful in methods of treating hyperuricemia. The engineered microbial cells of the present disclosure are also useful in methods of treating gout, and in particular chronic refractory gout.
Claims15
An engineered bacterial cell, the cell comprising:
- a first nucleic acid encoding an intracellular uric acid degrading polypeptide operatively linked to a constitutive heterologous promoter;
- and
- a second nucleic acid encoding a uric acid transporter operatively linked to a heterologous promoter, wherein the uric acid transporter transports uric acid into the engineered bacterial cell;
- wherein the engineered bacterial cell has increased intracellular uric acid degrading activity and has increased uric acid uptake activity as compared to an otherwise identical non-engineered bacterial cell that does not comprise the first and second nucleic acids.
1 more element
Dependencies are inferred from the claim text.