Method of treating inflammatory bowel disease

A method of treating inflammatory bowel disease in a subject in need thereof, the method comprising:

• (a) administering to the subject in need thereof an induction dose comprising from about 300 mg to about 1200 mg of a long acting α4β7 targeting molecule in a single injection or multiple injections;
• (b) administering subcutaneously to the subject in need thereof a first maintenance dose comprising from about 300 mg to about 450 mg of the long acting α4β7 targeting molecule,
• wherein the first maintenance dose is administered at least two weeks after administering the induction dose;
• and
• (c) administering subcutaneously to the subject in need thereof a second maintenance dose comprising from about 300 mg to about 450 mg of the long acting α4β7 targeting molecule to treat the subject in need thereof,
• wherein the induction dose comprises a same or higher amount of the long acting α4β7 targeting molecule than the first and the second maintenance doses,
• wherein the first and second maintenance doses comprise the long acting α4β7 targeting molecule at a concentration of at least 180 mg/mL, and wherein the first and second maintenance doses are administered at least twelve weeks apart,
• wherein the long acting α4β7 targeting molecule comprises:
• a heavy chain consisting of an amino acid sequence according to SEQ ID NO:
• 1;
• and
• a light chain consisting of an amino acid sequence according to SEQ ID NO:
• 3.