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US 12,703,743 B2Granted
Anti-CD47 monoclonal antibody and use thereof
AssigneeAkeso Biopharma, Inc.
InventorsPeng Zhang, Baiyong Li, Yu Xia, Zhongmin Wang
Life of this patent
Estimating the term…
Abstract
Provided are an anti-CD47 monoclonal antibody and a use thereof, secreted by the hybridoma cell line with the deposit number CCTCC NO: C2018135.
Claims23
An antibody or an antigen-binding fragment thereof that specifically binds to CD47, which, comprises HCDR1-3 and LCDR1-3 as shown below, wherein
- the amino acid sequences of the 3 CDR regions of the heavy chain variable region are as follows:
- HCDR1:
- (SEQ ID NO:
- 5)
- GYTFTSYW,
- HCDR2:
- (SEQ ID NO:
- 6)
- IDPSDSET,
- and
- HCDR3:
- (SEQ ID NO:
- 7)
- ARLYRWYFDV;
- and
- and
- the amino acid sequences of the 3 CDR regions of the light chain variable region are as follows:
- LCDR1:
- (SEQ ID NO:
- 8)
- EIVGTY,
- LCDR2:
- (SEQ ID NO:
- 9)
- GAS,
- and
- LCDR3:
- (SEQ ID NO:
- 10)
- GQSYNFPYT
27 more elements
A hybridoma cell line and a monoclonal antibody produced by the hybridoma cell line, wherein the hybridoma cell line is hybridoma cell line LT012 under CCTCC NO. 2018135.
Dependencies are inferred from the claim text.