GKN1 (gastrokine 1) specific antibody, and use thereof
AssigneeThe Catholic University of Korea Industry-Academic Cooperation Foundation
InventorsWon Sang Park, Jung Hwan Yoon
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Abstract
The present invention relates to a novel antibody specifically binding to a specific epitope of GKN1 (gastrokine 1) protein, and a gastric cancer diagnostic use thereof. An antibody specific to GKN1 according to the present invention specifically binds to a new epitope, and can be used to confirm the level of GKN1 protein in serum and thereby detect (diagnose) gastric cancer with 100% sensitivity and specificity. Thus, the antibody can be useful for screening and diagnosing gastric cancer.
Claims14
An isolated antibody specifically binding to a single epitope located in a BRICHOS domain of gastrokine 1 (GKN1) protein or an immunologically active fragment thereof, comprising:
- a light chain variable domain (VL) including a complementarity determining region light chain (CDRL) 1 including the amino acid sequence represented by SEQ ID NO:
- 2, a CDRL2 including the amino acid sequence represented by SEQ ID NO:
- 3, and a CDRL3 including the amino acid sequence represented by SEQ ID NO:
- 4;
- and
- a heavy chain variable domain (VH) including a complementarity determining region heavy chain (CDRH) 1 including the amino acid sequence represented by SEQ ID NO:
- 5, a CDRH2 including the amino acid sequence represented by SEQ ID NO:
- 6, and a CDRH3 including the amino acid sequence represented by SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.